the Virus Maraba is used in quality onkolitika
by The Ottawa Hospital Viruses bring a cancer immunotherapy to new level
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the Canadian oncologists checked on mice a combination of two methods of an immunotherapy of a cancer and with its help managed to cure from 60 to 90 percent of experimental animals of a form of a cancer of a breast hard to cure. New research in the Science Translational Medicine magazine.
Experimental therapy the group under the leadership of Mari - Burzhua Klod - Deyno from University developed Ottawa for treatment of the extremely aggressive form of a cancer of a mammary gland – so-called three times a negative cancer of a mammary gland (triple-negative breast cancer, TNBC). He received such name, as cells of a tumor of this type of a cancer not expressiruyut three types of receptors – an estrogen, a progesterone and an epidermalny factor of growth.
Group Burzhua Klod - Deyno applied at once two while a little widespread therapies – so-called onkolitichesky viruses (the modified viruses which breed only in cancer cells) and inhibitors of immune control points (monoclonal antibodies which block a so-called signal of PD-1 by means of which tumoral cages do not allow lymphocytes of to kill).
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"Our immune system constantly tries to distinguish and kill cancer cells, but cancer cells always try to disappear from it, – explains result the coauthor of article the doctor Bell John, professor of Ottavsky university. – When you infect a cancer cell with a virus, it hoists the big red colors which help immune system to distinguish and attack a cancer. But in some types of a cancer of it it is still not enough. We found out that when we add inhibitors of immune control points after a virus, it releases all "alarm signals" and the immune system sends the armies against a cancer in full strength".
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Burzhua Klod
Bell John